What is the maximum recommended duration for administering nitrous oxide?

The maximum recommended duration for administering nitrous oxide is 30 minutes due to the potential for diffusion hypoxia and other side effects that could arise with prolonged exposure. Nitrous oxide is a pharmacologically active agent that can lead to cumulative effects if used for extended periods. Keeping the administration time within this limit helps to minimize adverse reactions and ensures that the patient's exposure is within a safer range.

While nitrous oxide is generally well-tolerated, maintaining a shorter administration window helps healthcare providers monitor the effects closely and allows for an easier transition back to normal airway function and oxygenation. After approximately 30 minutes, the risks associated with the concentration of nitrous oxide in the patient's system increase, making it prudent to adhere to this guideline.

The other suggested durations either exceed the recommended limit or imply that safety concerns can be disregarded, which is not advisable in clinical practice.